Prognostic Impact of the Serum Levels of Soluble CD23 in B-Cell Chronic Lymphocytic Leukemia
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منابع مشابه
Prognostic impact of the serum levels of soluble CD23 in B-cell chronic lymphocytic leukemia.
E, Biondi F, Lo Coco F, Grignani F, Pelicci PG: Acute promyelocytic REFERENCES leukemia: From genetics to treatment. Blood 83:10, 1994 1. Wada H, Mizutani S, Nishimura J, Usuki Y, Kohsaki M, Komai 5. Nucifora G, Rowley JD: The AML1 and ETO genes in acute M, Kaneko H, Sakamoto S, Delia D, Kanamaru A, Kakishita E: myeloid leukemia with a t(8;21). Leuk Lymphoma 14:353, 1994 Establishment and molec...
متن کاملPrognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia.
Prognosis of B-cell chronic lymphocytic leukemia (CLL) is based on clinical staging whose limitation is the failure to assess whether the disease will progress or remain stable in early stage (Binet A, or Rai 0, I, II) patients. We previously reported that soluble CD23 (sCD23), a protein derived from the B-cell membrane CD23 Ag, is selectively elevated in the serum of CLL patients. This prospec...
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BACKGROUND CD23 is a functionally relevant molecule in B-cell chronic lymphocytic leukemia (CLL) which mediates growth and differentiation signals in B-cells. An intriguing feature of CD23 is its ability to be cleaved from the cell surface and released into the serum. MATERIALS AND METHODS Serum levels of soluble CD23 (sCD23) were determined with a sandwich enzyme immunoassay at the time of d...
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Members of the Notch family encode transmembrane receptors that modulate differentiation, proliferation, and apoptotic programs of many precursor cells, including hematopoietic progenitors. Stimulation of Notch causes cleavage followed by translocation of the intracellular domain (NotchIC) to the nucleus, where it activates transcription of CBF1 responsive genes. The aim of this study was to el...
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ژورنال
عنوان ژورنال: Blood
سال: 1997
ISSN: 1528-0020,0006-4971
DOI: 10.1182/blood.v89.11.4241